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- Title
Research on the preparation and antibacterial properties of 2- N-thiosemicarbazide-6-O-hydroxypropyl chitosan membranes with iodine.
- Authors
Sai, Mingze; Zhong, Shiliang; Tang, Yang; Ma, Wentao; Sun, Yangang; Ding, Derun
- Abstract
ABSTRACT The 2- N-thiosemicarbazide-6-O-hydroxypropyl chitosan (ATU-HPCS) was prepared by chitosan grafted hydroxypropyl and thiosemicarbazide through the method of 'amino protection-graft-deprotection,' while the ATU-HPCS gel membranes were obtained from gelatin and polyvinyl pyrrolidone as additives, and the ATU-HPCS membranes with iodine (ATU-HPCS-I2-M) were prepared by adding the ethanol solution of iodine in the ATU-HPCS gel membranes. The ATU-HPCS-I2-M were characterized to evaluate their potential applications as antibacterial materials. The iodine releasing rule of ATU-HPCS-I2-M showed a sustained-release effect of iodine, the maximum emission was approximately 0.80%. The inhibition zone diameters of ATU-HPCS-I2-M against Staphylococcus aureus (as Gram-positive bacteria) and Escherichia coli (as Gram-negative bacteria) were both greater than 15 mm, it demonstrated significant antibacterial activity compared with the ATU-HPCS gel membranes. The double effects of the biocompatibility of chitosan and the sustained-release of iodine provided an ideal healing environment for wound surface. These properties have made ATU-HPCS-I2-M highly potential as a novel natural macromolecule antimicrobial material preventing the bacteria from burns, surgery wounds, etc. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40535.
- Subjects
ANTIBACTERIAL agents; CHITOSAN; THERAPEUTIC use of iodine; ARTIFICIAL membranes; AMINO acids; STAPHYLOCOCCUS aureus infections; THERAPEUTICS
- Publication
Journal of Applied Polymer Science, 2014, Vol 131, Issue 15, pn/a
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.40535