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- Title
Agranulocytosis associated with aprindine and other antiarrhythmic drugs: an epidemiological approach.
- Authors
IBÁÑEZ, L.; JUAN, J.; PÉREZ, E.; CARNÉ, X.; LAPORTE, J. R.
- Abstract
The risk of agranulocytosis associated with anti-arrhythmic drugs has been assessed by studying previous drug exposure of all cases collected through a muiticentre surveillance network in a defined geographical area during the period 1980–1988. One hundred and eighty-one patients with agranulocytosis (<500 granulocytes mm at least in two different blood counts) were interviewed with a structured questionnaire. Eight cases attributable to anti-arrhythmic drugs were identified, all of them related to aprindine. Data on the consumption of several anti-arrhythmic drugs (amiodarone, aprindine, quinidine, propafenone) were obtained in order to estimate the risk of agranulocytosis related with the previous use of these drugs. A relevant risk was identjfied only for aprindine, of the order of two cases per 1000 patient-years. Our data suggest that the risk of agranulocytosis associated with aprindine is lower than previously found.
- Publication
European Heart Journal, 1991, Vol 12, Issue 5, p639
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/oxfordjournals.eurheartj.a059953