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- Title
Cascade Reactions in Multicompartmentalized Polymersomes.
- Authors
Peters, Ruud J. R. W.; Marguet, Maïté; Marais, Sébastien; Fraaije, Marco W.; van Hest, Jan C. M.; Lecommandoux, Sébastien
- Abstract
Enzyme-filled polystyrene- b-poly(3-(isocyano- L-alanyl-aminoethyl)thiophene) (PS- b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene- b-poly(ethylene oxide) (PB- b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.
- Subjects
POLYMERSOMES; POLYBUTADIENE; DNA replication; EUKARYOTIC cells; CARBON fixation; MONOOXYGENASES
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 1, p146
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201308141