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- Title
Failure of cefotaxime treatment in two children with meningitis caused by highly penicillin-resistant Streptococcus pneumoniae.
- Authors
Guibert, M; Chahime, H; Petit, J; Odievre, M; Labrune, Ph; Odièvre, M; Labrune, P
- Abstract
Two infants, aged 8.5 and 11 months, were admitted for meningitis caused by Streptococcus pneumoniae. Failure of cefotaxime led to the identification of highly penicillin-G-resistant strains. Minimum inhibitory concentrations (MICs) for penicillin were > 2 micrograms/ml, and cefotaxime MICs were 2 micrograms/ml. Both patients rapidly responded to a combination of i.v. imipenem and rifampicin. It is now mandatory to test in-vitro susceptibilities of Streptococcus pneumoniae to penicillin G and other beta-lactam agents when meningitis is diagnosed in infants.
- Publication
Acta Paediatrica, 1995, Vol 84, Issue 7, p831
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/j.1651-2227.1995.tb13771.x