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- Title
Cryoglobulinemia as a Possible Primer for TRALI: Report of a Case.
- Authors
Beech, Cameron; Kumar, Deepika; Hendrickson, Jeanne; Perincheri, Sudhir; Tormey, Christopher; Bahar, Burak
- Abstract
Waldenström macroglobulinemia (WM) is a form of lymphoplasmacytic lymphoma that can cause hyperviscosity syndrome due to unchecked monoclonal antibody production. Some patients are also found to have associated cryoglobulinemia, which can cause systemic complications including vasculitis, renal disease, and pulmonary complications. Cryoglobulins can also serve as a source of interference with various laboratory assays. Therapeutic plasma exchange (TPE) is one of the recommended treatment modalities to manage hyperviscosity. Herein, we present the case of an 84-year-old female patient with Waldenström macroglobulinemia who presented with hyperviscosity syndrome and discrepant laboratory findings, and who then developed transfusion-related acute lung injury (TRALI) during TPE. This case is one of many in the emerging possible linkages observed between cryoglobulinemia and TRALI.
- Subjects
COLLECTION &; preservation of biological specimens; BLOOD diseases; BLOOD transfusion reaction; BLOOD viscosity; VASCULAR diseases; CLINICAL pathology; HEMAPHERESIS; HEMOSTASIS; LUNG injuries; LYMPHOPROLIFERATIVE disorders; PLASMA exchange (Therapeutics)
- Publication
Laboratory Medicine, 2019, Vol 50, Issue 3, p313
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmy073