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- Title
Effects of renin-angiotensin system inhibitors on histopathology of pancreas in experimental chronic pancreatitis.
- Authors
MąDro, Agnieszka; Czechowska, Grażyna; Korolczuk, Agnieszka; Celińskil, Knysztof; Słomka, Maria; Prozorow-Król, Beata; Korobowlcz, Elżbieta
- Abstract
Introduction: Chronic pancreatitis (CP) is a progressive disease, in which the exocrine function of the gland is gradually lost and fibrosis develops due to repeated episodes of acute pancreatitis. The detection of the renin-angiotensin system (RAS) brings us closer to understanding the pathogenesis of CP. It was observed that the use of RAS inhibitors reduced hepatic fibrosis. Aim of study: The aim of the study was to examine the effects of RAS inhibitors on fibrotic processes in the course of experimental chronic pancreatitis induced by dibutyltin dichloride (DD). Material and methods: Chronic pancreatitis was induced by administration of dibutyltin dichloride to the femoral vein. Simultaneously captopril, losartan and enalapril were administered intraperitoneally. The rats were decapitated after 60 days and tissue of pancreas was collected for histopathological examination. Results: In control group no pathological changes were observed. In rats treated by dibutyltin dichloride the features of focal inflammatory infiltration, ductal lumen dilatation, fibrosis in the periductal spaces and slight interstitial fibrosis were found. In animals treated by RAS inhibitor inflammatory changes and fibrosis were less severe, particularly in rats treated by enalapril. Conclusions: The findings suggest that enalapril inhibits inflammatory changes and fibrosis most effectively.
- Subjects
RENIN-angiotensin system; REGULATION of blood pressure; ENZYME inhibitors; HISTOPATHOLOGY; PANCREATITIS; PANCREATIC diseases
- Publication
Gastroenterologia Polska / Gastroenterology, 2007, Vol 14, Issue 4, p277
- ISSN
1232-9886
- Publication type
Article