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- Title
Cobalt-Catalyzed C−H Thiolation through Dehydrogenative Cross-Coupling.
- Authors
Gensch, Tobias; Klauck, Felix J. R.; Glorius, Frank
- Abstract
A cobalt-catalyzed dehydrogenative cross-coupling of thiols and indoles is reported. Using a cooperative reaction system, a new mode of action for the cobalt-catalyzed C−heteroatom bond formation was found. The directed C−H activation catalysis overrides an undirected thiolation of indole in the 3-position that occurs in the absence of cobalt. Mechanistic studies indicate a sequence of C−H activation, thiolate transfer, and reductive elimination.
- Subjects
COBALT catalysts; COUPLING agents (Chemistry); COUPLING reactions (Chemistry); CHEMICAL reactions; THIOL synthesis; INDOLE compounds
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 37, p11287
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201605193