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- Title
Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis.
- Authors
Castro, Michael J.; Kent-Braun, Jane A.; Ng, A.V.; Miller, Robert G.; Dudley, Gary A.; Castro, M J; Kent-Braun, J A; Miller, R G; Dudley, G A
- Abstract
Biopsies of tibialis anterior muscle were analyzed to determine if increased energy demand of contraction, as indirectly reflected by myofibrillar actomyosin Ca2+ ATPase (qATPase) activity, contributes to symptomatic fatigue in multiple sclerosis (MS). qATPase activity showed a fiber-type effect, IIax > IIa > I. Fiber-type qATPase activity, however, was not different between MS patients and healthy controls. We suggest that fatigue in MS does not reflect increased energy demand of contraction.
- Publication
Muscle & Nerve, 1998, Vol 21, Issue 4, p547
- ISSN
0148-639X
- Publication type
journal article
- DOI
10.1002/(SICI)1097-4598(199804)21:4<547::AID-MUS18>3.0.CO;2-U