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- Title
Use of a human tumor cloning system to screen retinoids for antineoplastic activity.
- Authors
Cowan, John D.; Von Hoff, Daniel D.; Dinesman, Allen; Clark, Gary; Cowan, J D; Von Hoff, D D; Dinesman, A; Clark, G
- Abstract
Retinoid analogs are being actively evaluated as antitumor agents in man. A human tumor cloning system was used to assess the antineoplastic activity of all-trans-retinoic acid, all-trans-retinol and 13-cis-retinoic acid. The effect of retinoids on the formation of tumor colony forming units (T-CFU) was surveyed for 67 different human tumors. These analogs showed minor activity in a variety of neoplasms. The decrease in T-CFU varied between histologic tumor types and between tumor of the same type. No significant difference between retinoid analogs was noted.
- Publication
Cancer (0008543X), 1983, Vol 51, Issue 1, p92
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19830101)51:1<92::AID-CNCR2820510119>3.0.CO;2-R