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- Title
Herpes zoster and varicella infections in children with Hodgkin's disease: an analysis of contributing factors.
- Authors
Reboul, Francois; Donaldson, Sarah S.; Kaplan, Henry S.; Reboul, F; Donaldson, S S; Kaplan, H S
- Abstract
181 children with Hodgkin's disease were analyzed with respect to the occurrence of herpes zoster and varicella (HZ-V) infections, possible contributing factors, and prognostic significance. The overall frequency of HZ-V was 34.8%. The occurrence in stage I was significantly lower than in other stages. Previous splenectomy was not found to increase significantly the risk of infection. High-risk patients were those receiving extensive radiotherapy plus combination chemotherapy; 56% developed HZ-V infections in this group. The frequency with extensive field radiotherapy alone was 23.8%. 80% of infections occurred during the first year after completion of treatment. Their occurrence was not a poor prognostic sign in terms of relapse or fatality, even when occurring late. The high frequency of disseminated infection (27%) with its subsequent morbidity should lead toward a better understanding of the immunologic deficiencies in these patients and the possible role of prophylactic measures, in patients undergoing extensive radiotherapy in combination with multiagent chemotherapy.
- Publication
Cancer (0008543X), 1978, Vol 41, Issue 1, p95
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197801)41:1<95::AID-CNCR2820410114>3.0.CO;2-Q