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- Title
Immunochemotherapy in human lung cancer using the streptococcal agent OK-432.
- Authors
Kimura, Ikuro; Ohnoshi, Taisuke; Yasuhara, Shozo; Sugiyama, Motoharu; Urabe, Yasuo; Fujii, Masafumi; Machida, Ken-Ich; Kimura, I; Ohnoshi, T; Yasuhara, S; Sugiyama, M; Urabe, Y
- Abstract
Streptococcal agent OK-432 was administered at maintenance levels with conventional inductive chemotherapeutic agents to stage III and IV lung cancer patients. Survival rates were longer in patients treated with OK-432 than in patients treated without OK-432. An enhancement of lymphocyte blastogenic activity and a delayed PPD skin reaction were found in patients treated by OK-432. A low grade fever was present as a side effect of this agent in some patients. The results suggest that OTK-432 may be useful immunotherapeutic agent in combination with induction chemotherapy in reducing host damage in advanced stages of lung cancer.
- Publication
Cancer (0008543X), 1976, Vol 37, Issue 5, p2201
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197605)37:5<2201::AID-CNCR2820370507>3.0.CO;2-Q