We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Vesicular Acetylcholine Transporter Is Present in Melanocytes and Keratinocytes in the Human Epidermis.
- Authors
Elwary, Souna M. A.; Chavan, Bhaven; Schallreuter, Karin U.
- Abstract
The human epidermis holds the full machinery for cholinergic signal transduction. However, the presence of the vesicular transporter (vesicular acetylcholine (ACh) transporter (VAChT)) for both choline and ACh has never been shown in this compartment. The results of this study confirm the presence of VAChT in cutaneous nerves and in both epidermal melanocytes and keratinocytes as well as in their nuclei using immunofluorescence labelling in situ and in vitro, Western blot analysis of cellular and nuclear extracts and reverse transcription-PCR. These results underline that ACh/choline transport in the non-neuronal epidermis is no different from the neuronal pathway. However, the function of VAChT in the nucleus remains to be shown.Journal of Investigative Dermatology (2006) 126, 1879–1884. doi:10.1038/sj.jid.5700268; published online 8 June 2006
- Subjects
EPITHELIAL cells; KERATINOCYTES; EPIDERMIS; SKIN; SKIN diseases; CELLS; VITAMIN B complex
- Publication
Journal of Investigative Dermatology, 2006, Vol 126, Issue 8, p1879
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/sj.jid.5700268