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- Title
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
- Authors
Orr, Nick; Lemnrau, Alina; Cooke, Rosie; Fletcher, Olivia; Tomczyk, Katarzyna; Jones, Michael; Johnson, Nichola; Lord, Christopher J; Mitsopoulos, Costas; Zvelebil, Marketa; McDade, Simon S; Buck, Gemma; Blancher, Christine; Trainer, Alison H; James, Paul A; Bojesen, Stig E; Bokmand, Susanne; Nevanlinna, Heli; Mattson, Johanna; Friedman, Eitan
- Abstract
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10?13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10?15; OR = 1.50).
- Subjects
GENOMES; MALE breast cancer; SINGLE nucleotide polymorphisms; DISEASE risk factors; HUMAN genome; EPIDEMIOLOGY
- Publication
Nature Genetics, 2012, Vol 44, Issue 11, p1182
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2417