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- Title
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
- Authors
van Haaften, Gijs; Dalgliesh, Gillian L.; Davies, Helen; Chen, Lina; Bignell, Graham; Greenman, Chris; Edkins, Sarah; Hardy, Claire; O'Meara, Sarah; Teague, Jon; Butler, Adam; Hinton, Jonathan; Latimer, Calli; Andrews, Jenny; Barthorpe, Syd; Beare, Dave; Buck, Gemma; Campbell, Peter J.; Cole, Jennifer; Forbes, Simon
- Abstract
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
- Subjects
HISTONES; CANCER; LYSINE; GENETIC regulation; CANCER cells; MOLECULAR genetics; GENE expression; GENETIC research
- Publication
Nature Genetics, 2009, Vol 41, Issue 5, p521
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.349