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- Title
The Human in Vitro Anti-type 4 Pneumococcal Polysaccharide Antibody Response is Regulated by Suppressor T Cells.
- Authors
Griffioen, A. W.; Rijkers, G. T.; Toebes, E. A. H.; Zegers, B. J. M.
- Abstract
In order to study the regulation of the human B-cell response to T-cell independent type 2 (TI-2) antigens, we analysed the role of T cells in the in vitro antibody response to type 4 pneumococcal polysaccharide (PS4), We found that T cells can positively regulate the in vitro antibody response to PS4 when they arc added into an in vitro B-ceil culture system, In addition we demonstrated that T cells exert a negatively regulating activity. We found that T cells, when cultured T or 24 h in the presence of high concentrations of PS4, can suppress the anti-PS4 antibody response. This down-regulation of the anti-PS4 B-cell response is shown to be antigen specific and MHC restricted, Furthermore. PS4-specific T-cell mediated suppression appears to be radioresistant and confined to the T-ceil preparations enriched for CD8+ cells. The results show that analogous to results obtained in mice, human T cells are able to exert a regulatory control of the antibody response to Ti-2 antigens.
- Subjects
LYMPHOCYTES; LEUCOCYTES; IMMUNOGLOBULINS; ANTIGENS; IMMUNITY; T cells
- Publication
Scandinavian Journal of Immunology, 1991, Vol 34, Issue 2, p229
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb01541.x