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- Title
la Antigens on Antigen-presenting Cells do not Carry the Same la Specificities as Detected on Suppressor and Helper T Cells.
- Authors
Asano, Y.; Okumura, K.; Tada, T.
- Abstract
The passage of spleen cells through a tightly packed nylon wool column partially separated two populations of cells required for the antigen-induced secondary proliferative response of T cells. The proliferating T cells were in the nylon wool column-passed cell population, but the addition of a small number of nylon-wool-adherent ceils was required for their maximal proliferative response. Such adherent cells were non-T, non-B, Ia antigen-positive cells serving as antigen- presenting cells. Ia determinants on this cell type arc encoded in two separate 1 subregions, I-A and I-E/C, and they are expressed simultaneously on the same cells. Antisera specific for I-J subregion gene products having as a known activity the killing of antigen-specific suppressor and helper T cells were unable to kill antigen-presenting adherent cells. The results indicated that at least I-J subregion gent products expressed on suppressor and helper T cells are not present on antigen-presenting accessory cells. The Ia specificities detected on accessory cells follow the cross-reactive pattern found in Ia molecules of B cells, and thus antigen-presenting cells carry Ia antigen identical to those of B cells, and not those of T cells.
- Subjects
T cells; ANTIGENS; ANTIGEN presenting cells; IMMUNE serums; IMMUNOGENETICS; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1981, Vol 13, Issue 4, p353
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1981.tb00144.x