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- Title
Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles.
- Authors
Motoyama, Jun; Yamashita, Noriyuki; Morino, Tomio; Tanaka, Masashi; Kobayashi, Takeshi; Honda, Hiroyuki
- Abstract
Background: We have developed magnetite cationic liposomes (MCLs) and applied them as a mediator of local hyperthermia. MCLs can generate heat under an alternating magnetic field (AMF). In this study, the in vivo effect of hyperthermia mediated by MCLs was examined using 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary cancer as a spontaneous cancer model. Method: MCLs were injected into the mammary cancer and then subjected to an AMF. Results: Four rats in 20 developed mammary tumors at more than 1 site in the body. The first-developed tumor in each of these 4 rats was selected and heated to over 43°C following administration of MCLs by an infusion pump. After a series of 3 hyperthermia treatments, treated tumors in 3 of the 4 rats were well controlled over a 30-day observation period. One of the 4 rats exhibited regrowth after 2 weeks. In this rat, there were 3 sites of tumor regrowth. Two of these regrowths were reduced in volume and regressed completely after 31 days, although the remaining one grew rapidly. These results indicated hyperthermia-induced immunological antitumor activity mediated by the MCLs. Conclusion: Our results suggest that hyperthermic treatment using MCLs is effective in a spontaneous cancer model.
- Subjects
ANIMAL health; ANIMAL experimentation; CANCER treatment; NANOPARTICLES; THERAPEUTICS
- Publication
BioMagnetic Research & Technology, 2008, Vol 6, p1
- ISSN
1477-044X
- Publication type
Article
- DOI
10.1186/1477-044X-6-2