We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Painful scrotal dermatitis secondary to topical 5-fluorouracil.
- Authors
Yi, Julie Z.; Himes, Richard S.; Smith, Robert J.; McKee, Phillip H.; Roberts, Alice A.
- Abstract
5-Fluorouracil (5-FU) is an antineoplastic agent that is used topically to treat actinic keratoses. Although topical 5-FU frequently causes irritant contact dermatitis at the site of application, distant skin reactions are rare and could relate to accidental transfer or systemic absorption of the drug. We present a patient who developed a painful scrotal dermatitis after applying the topical cream to actinic keratoses on his chest. Upon discontinuation of topical 5-FU, the reaction resolved over a four-week period with oral prednisone and topical betamethasone ointment. The patient was re-challenged with topical 5-FU one year later and again developed scrotal pain and erythema similar to the initial reaction. Scrotal dermatitis is a rare adverse effect of topical 5-FU therapy that can be associated with significant distress and disruption of daily activities.
- Subjects
FLUOROURACIL; SKIN inflammation; KERATOSIS; PREDNISONE; ORAL medication
- Publication
Dermatology Online Journal, 2021, Vol 27, Issue 6, p1
- ISSN
1087-2108
- Publication type
Article
- DOI
10.5070/D327654060