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Conformational Changes in HIV-1 Env Trimer Induced by a Single CD4 as Revealed by Cryo-EM.
Published in:
Microscopy & Microanalysis, 2017, v. 23, p. 1190, doi. 10.1017/S1431927617006614
By:
- Acharya, Priyamvada;
- Qingbo Liu;
- Xiaochu Ma;
- Maolin Lu;
- Dandey, Venkat;
- Eng, Edward T.;
- Rice, William J.;
- Wigge, Christoph;
- Bylund, Tatsiana;
- Gwo-Yu Chuang;
- Druz, Aliaksandr;
- Hui Geng;
- Gorman, Jason;
- Tongqing Zhou;
- Mothes, Walther;
- Lusso, Paolo;
- Carragher, Bridget;
- Potter, Clinton S.;
- Kwong, Peter D.
Publication type:
Article
An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans.
Published in:
Science Translational Medicine, 2023, v. 15, n. 692, p. 1, doi. 10.1126/scitranslmed.ade4976
By:
- Andrews, Sarah F.;
- Cominsky, Lauren Y.;
- Shimberg, Geoffrey D.;
- Gillespie, Rebecca A.;
- Gorman, Jason;
- Raab, Julie E.;
- Brand, Joshua;
- Creanga, Adrian;
- Gajjala, Suprabhath R.;
- Narpala, Sandeep;
- Cheung, Crystal S. F.;
- Harris, Darcy R.;
- Zhou, Tongqing;
- Gordon, Ingelise;
- Holman, LaSonji;
- Mendoza, Floreliz;
- Houser, Katherine V.;
- Chen, Grace L.;
- Mascola, John R.;
- Graham, Barney S.
Publication type:
Article
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.
Published in:
Nature, 2015, v. 519, n. 7541, p. 87, doi. 10.1038/nature14264
By:
- Gardner, Matthew R.;
- Kattenhorn, Lisa M.;
- Kondur, Hema R.;
- von Schaewen, Markus;
- Dorfman, Tatyana;
- Chiang, Jessica J.;
- Haworth, Kevin G.;
- Decker, Julie M.;
- Alpert, Michael D.;
- Bailey, Charles C.;
- Neale, Ernest S.;
- Fellinger, Christoph H.;
- Joshi, Vinita R.;
- Fuchs, Sebastian P.;
- Martinez-Navio, Jose M.;
- Quinlan, Brian D.;
- Yao, Annie Y.;
- Mouquet, Hugo;
- Gorman, Jason;
- Zhang, Baoshan
Publication type:
Article
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Published in:
Nature, 2014, v. 514, n. 7523, p. 455, doi. 10.1038/nature13808
By:
- Pancera, Marie;
- Zhou, Tongqing;
- Druz, Aliaksandr;
- Georgiev, Ivelin S.;
- Soto, Cinque;
- Gorman, Jason;
- Acharya, Priyamvada;
- Chuang, Gwo-Yu;
- Ofek, Gilad;
- Stewart-Jones, Guillaume B. E.;
- Stuckey, Jonathan;
- Bailer, Robert T.;
- Joyce, M. Gordon;
- Louder, Mark K.;
- Yang, Yongping;
- Zhang, Baoshan;
- Mascola, John R.;
- Kwong, Peter D.;
- Huang, Jinghe;
- Connors, Mark
Publication type:
Article
HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.
Published in:
eLife, 2018, p. 1, doi. 10.7554/eLife.34271
By:
- Xiaochu Ma;
- Maolin Lu;
- Gorman, Jason;
- Terry, Daniel S.;
- Xinyu Hong;
- Zhou Zhou;
- Hong Zhao;
- Altman, Roger B.;
- Arthos, James;
- Blanchard, Scott C.;
- Kwong, Peter D.;
- Munro, James B.;
- Mothes, Walther
Publication type:
Article
Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.
Published in:
PLoS Pathogens, 2017, v. 13, n. 1, p. 1, doi. 10.1371/journal.ppat.1006074
By:
- Wibmer, Constantinos Kurt;
- Gorman, Jason;
- Ozorowski, Gabriel;
- Bhiman, Jinal N.;
- Sheward, Daniel J.;
- Elliott, Debra H.;
- Rouelle, Julie;
- Smira, Ashley;
- Joyce, M. Gordon;
- Ndabambi, Nonkululeko;
- Druz, Aliaksandr;
- Asokan, Mangai;
- Burton, Dennis R.;
- Connors, Mark;
- Abdool Karim, Salim S.;
- Mascola, John R.;
- Robinson, James E.;
- Ward, Andrew B.;
- Williamson, Carolyn;
- Kwong, Peter D.
Publication type:
Article
Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.
Published in:
2016
By:
- Mason, Rosemarie D.;
- Welles, Hugh C.;
- Adams, Cameron;
- Chakrabarti, Bimal K.;
- Gorman, Jason;
- Zhou, Tongqing;
- Nguyen, Richard;
- O’Dell, Sijy;
- Lusvarghi, Sabrina;
- Bewley, Carole A.;
- Li, Hui;
- Shaw, George M.;
- Sheng, Zizhang;
- Shapiro, Lawrence;
- Wyatt, Richard;
- Kwong, Peter D.;
- Mascola, John R.;
- Roederer, Mario
Publication type:
Correction Notice
Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.
Published in:
PLoS Pathogens, 2016, v. 12, n. 4, p. 1, doi. 10.1371/journal.ppat.1005537
By:
- Mason, Rosemarie D.;
- Welles, Hugh C.;
- Adams, Cameron;
- Chakrabarti, Bimal K.;
- Gorman, Jason;
- Zhou, Tongqing;
- Nguyen, Richard;
- O’Dell, Sijy;
- Lusvarghi, Sabrina;
- Bewley, Carole A.;
- Li, Hui;
- Shaw, George M.;
- Sheng, Zizhang;
- Shapiro, Lawrence;
- Wyatt, Richard;
- Kwong, Peter D.;
- Mascola, John R.;
- Roederer, Mario
Publication type:
Article
Amontons-Coulomb-like slip dynamics in acousto-microfluidics.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28823-6
By:
- Quelennec, Aurore;
- Gorman, Jason J.;
- Reyes, Darwin R.
Publication type:
Article
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Published in:
Nature, 2014, v. 509, n. 7498, p. 55, doi. 10.1038/nature13036
By:
- Doria-Rose, Nicole A.;
- Schramm, Chaim A.;
- Gorman, Jason;
- Moore, Penny L.;
- Bhiman, Jinal N.;
- DeKosky, Brandon J.;
- Ernandes, Michael J.;
- Georgiev, Ivelin S.;
- Kim, Helen J.;
- Pancera, Marie;
- Staupe, Ryan P.;
- Altae-Tran, Han R.;
- Bailer, Robert T.;
- Crooks, Ema T.;
- Cupo, Albert;
- Druz, Aliaksandr;
- Garrett, Nigel J.;
- Hoi, Kam H.;
- Kong, Rui;
- Louder, Mark K.
Publication type:
Article
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Published in:
Nature, 2011, v. 480, n. 7377, p. 336, doi. 10.1038/nature10696
By:
- McLellan, Jason S.;
- Pancera, Marie;
- Carrico, Chris;
- Gorman, Jason;
- Julien, Jean-Philippe;
- Khayat, Reza;
- Louder, Robert;
- Pejchal, Robert;
- Sastry, Mallika;
- Dai, Kaifan;
- O'Dell, Sijy;
- Patel, Nikita;
- Shahzad-ul-Hussan, Syed;
- Yang, Yongping;
- Zhang, Baoshan;
- Zhou, Tongqing;
- Zhu, Jiang;
- Boyington, Jeffrey C.;
- Chuang, Gwo-Yu;
- Diwanji, Devan
Publication type:
Article
THE DRIEST DROUGHT: ABILENE, TEXAS AND ITS RELATIONSHIP WITH ALCOHOL.
Published in:
Touchstone, 2014, v. 33, p. 75
By:
- GORMAN, JASON
Publication type:
Article
Femtometer-amplitude imaging of coherent super high frequency vibrations in micromechanical resonators.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28223-w
By:
- Shao, Lei;
- Gokhale, Vikrant J.;
- Peng, Bo;
- Song, Penghui;
- Cheng, Jingjie;
- Kuo, Justin;
- Lal, Amit;
- Zhang, Wen-Ming;
- Gorman, Jason J.
Publication type:
Article
Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26579-z
By:
- Lee, Myungjin;
- Changela, Anita;
- Gorman, Jason;
- Rawi, Reda;
- Bylund, Tatsiana;
- Chao, Cara W.;
- Lin, Bob C.;
- Louder, Mark K.;
- Olia, Adam S.;
- Zhang, Baoshan;
- Doria-Rose, Nicole A.;
- Zolla-Pazner, Susan;
- Shapiro, Lawrence;
- Chuang, Gwo-Yu;
- Kwong, Peter D.
Publication type:
Article
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24291-6
By:
- Xu, Kai;
- Wang, Yiran;
- Shen, Chen-Hsiang;
- Chen, Yiwei;
- Zhang, Baoshan;
- Liu, Kevin;
- Tsybovsky, Yaroslav;
- Wang, Shuishu;
- Farney, S. Katie;
- Gorman, Jason;
- Stephens, Tyler;
- Verardi, Raffaello;
- Yang, Yongping;
- Zhou, Tongqing;
- Chuang, Gwo-Yu;
- Lanzavecchia, Antonio;
- Piccoli, Luca;
- Kwong, Peter D.
Publication type:
Article
Cavity Optomechanical Bistability with an Ultrahigh Reflectivity Photonic Crystal Membrane.
Published in:
Laser & Photonics Reviews, 2023, v. 17, n. 10, p. 1, doi. 10.1002/lpor.202300008
By:
- Zhou, Feng;
- Bao, Yiliang;
- Gorman, Jason J.;
- Lawall, John R.
Publication type:
Article
Transplanting Supersites of HIV-1 Vulnerability.
Published in:
PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0099881
By:
- Zhou, Tongqing;
- Zhu, Jiang;
- Yang, Yongping;
- Gorman, Jason;
- Ofek, Gilad;
- Srivatsan, Sanjay;
- Druz, Aliaksandr;
- Lees, Christopher R.;
- Lu, Gabriel;
- Soto, Cinque;
- Stuckey, Jonathan;
- Burton, Dennis R.;
- Koff, Wayne C.;
- Connors, Mark;
- Kwon, Peter D.
Publication type:
Article
N332-Directed Broadly Neutralizing Antibodies Use Diverse Modes of HIV-1 Recognition: Inferences from Heavy-Light Chain Complementation of Function.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055701
By:
- Pancera, Marie;
- Yang, Yongping;
- Louder, Mark K.;
- Gorman, Jason;
- Lu, Gabriel;
- McLellan, Jason S.;
- Stuckey, Jonathan;
- Zhu, Jiang;
- Burton, Dennis R.;
- Koff, Wayne C.;
- Mascola, John R.;
- Kwong, Peter D.
Publication type:
Article
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies.
Published in:
Nature Medicine, 2015, v. 21, n. 11, p. 1332, doi. 10.1038/nm.3963
By:
- Bhiman, Jinal N;
- Anthony, Colin;
- Doria-Rose, Nicole A;
- Karimanzira, Owen;
- Schramm, Chaim A;
- Khoza, Thandeka;
- Kitchin, Dale;
- Botha, Gordon;
- Gorman, Jason;
- Garrett, Nigel J;
- Abdool Karim, Salim S;
- Shapiro, Lawrence;
- Williamson, Carolyn;
- Kwong, Peter D;
- Mascola, John R;
- Morris, Lynn;
- Moore, Penny L
Publication type:
Article
Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes.
Published in:
NPJ Vaccines, 2020, v. 5, n. 1, p. 1, doi. 10.1038/s41541-020-00260-w
By:
- Verardi, Raffaello;
- Lindesmith, Lisa C.;
- Tsybovsky, Yaroslav;
- Gorman, Jason;
- Chuang, Gwo-Yu;
- Edwards, Caitlin E.;
- Brewer-Jensen, Paul D.;
- Mallory, Michael L.;
- Ou, Li;
- Schön, Arne;
- Shi, Wei;
- Tully, Ena S.;
- Georgiou, George;
- Baric, Ralph S.;
- Kwong, Peter D.
Publication type:
Article
Development of Neutralization Breadth against Diverse HIV‐1 by Increasing Ab–Ag Interface on V2.
Published in:
Advanced Science, 2022, v. 9, n. 15, p. 1, doi. 10.1002/advs.202200063
By:
- Gao, Nan;
- Gai, Yanxin;
- Meng, Lina;
- Wang, Chu;
- Wang, Wei;
- Li, Xiaojun;
- Gu, Tiejun;
- Louder, Mark K.;
- Doria‐Rose, Nicole A.;
- Wiehe, Kevin;
- Nazzari, Alexandra F.;
- Olia, Adam S.;
- Gorman, Jason;
- Rawi, Reda;
- Wu, Wenmin;
- Smith, Clayton;
- Khant, Htet;
- de Val, Natalia;
- Yu, Bin;
- Luo, Junhong
Publication type:
Article
Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12423-x
By:
- Cai, Cindy X.;
- Doria-Rose, Nicole A.;
- Schneck, Nicole A.;
- Ivleva, Vera B.;
- Tippett, Brad;
- Shadrick, William R.;
- O'Connell, Sarah;
- Cooper, Jonathan W.;
- Schneiderman, Zachary;
- Zhang, Baoshan;
- Gowetski, Daniel B.;
- Blackstock, Daniel;
- Demirji, Jacob;
- Lin, Bob C.;
- Gorman, Jason;
- Liu, Tracy;
- Li, Yile;
- McDermott, Adrian B.;
- Kwong, Peter D.;
- Carlton, Kevin
Publication type:
Article
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.662909
By:
- Chuang, Gwo-Yu;
- Shen, Chen-Hsiang;
- Cheung, Crystal Sao-Fong;
- Gorman, Jason;
- Creanga, Adrian;
- Joyce, M. Gordon;
- Leung, Kwanyee;
- Rawi, Reda;
- Wang, Lingshu;
- Yang, Eun Sung;
- Yang, Yongping;
- Zhang, Baoshan;
- Zhang, Yi;
- Kanekiyo, Masaru;
- Zhou, Tongqing;
- DeKosky, Brandon J.;
- Graham, Barney S.;
- Mascola, John R.;
- Kwong, Peter D.
Publication type:
Article
Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-023-44534-y
By:
- Gorman, Jason;
- Cheung, Crystal Sao-Fong;
- Duan, Zhijian;
- Ou, Li;
- Wang, Maple;
- Chen, Xuejun;
- Cheng, Cheng;
- Biju, Andrea;
- Sun, Yaping;
- Wang, Pengfei;
- Yang, Yongping;
- Zhang, Baoshan;
- Boyington, Jeffrey C.;
- Bylund, Tatsiana;
- Charaf, Sam;
- Chen, Steven J.;
- Du, Haijuan;
- Henry, Amy R.;
- Liu, Tracy;
- Sarfo, Edward K.
Publication type:
Article
Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4.
Published in:
PLoS Pathogens, 2022, v. 18, n. 6, p. 1, doi. 10.1371/journal.ppat.1010574
By:
- Welles, Hugh C.;
- King, Hannah A. D.;
- Nettey, Leonard;
- Cavett, Nicole;
- Gorman, Jason;
- Zhou, Tongqing;
- Tsybovsky, Yaroslav;
- Du, Renguang;
- Song, Kaimei;
- Nguyen, Richard;
- Ambrozak, David;
- Ransier, Amy;
- Schramm, Chaim A.;
- Doria-Rose, Nicole A.;
- Swanstrom, Adrienne E.;
- Hoxie, James A.;
- LaBranche, Celia;
- Montefiori, David C.;
- Douek, Daniel C.;
- Kwong, Peter D.
Publication type:
Article
Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1399960
By:
- Olia, Adam S.;
- Prabhakaran, Madhu;
- Harris, Darcy R.;
- Cheung, Crystal Sao-Fong;
- Gillespie, Rebecca A.;
- Gorman, Jason;
- Hoover, Abigayle;
- Morano, Nicholas C.;
- Ourahmane, Amine;
- Srikanth, Abhinaya;
- Shuishu Wang;
- Weiwei Wu;
- Tongqing Zhou;
- Andrews, Sarah F.;
- Masaru Kanekiyo;
- Shapiro, Lawrence;
- McDermott, Adrian B.;
- Kwong, Peter D.
Publication type:
Article
Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide.
Published in:
Protein Science: A Publication of the Protein Society, 2005, v. 14, n. 12, p. 3004, doi. 10.1110/ps.051680805
By:
- Gorman, Jason;
- Shapiro, Lawrence
Publication type:
Article
Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies.
Published in:
Immunological Reviews, 2017, v. 275, n. 1, p. 217, doi. 10.1111/imr.12501
By:
- Moore, Penny L.;
- Gorman, Jason;
- Doria-Rose, Nicole A.;
- Morris, Lynn
Publication type:
Article
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.
Published in:
Nature Structural & Molecular Biology, 2015, v. 22, n. 7, p. 522, doi. 10.1038/nsmb.3051
By:
- Do Kwon, Young;
- Pancera, Marie;
- Acharya, Priyamvada;
- Georgiev, Ivelin S;
- Crooks, Emma T;
- Gorman, Jason;
- Joyce, M Gordon;
- Guttman, Miklos;
- Ma, Xiaochu;
- Narpala, Sandeep;
- Soto, Cinque;
- Terry, Daniel S;
- Yang, Yongping;
- Zhou, Tongqing;
- Ahlsen, Goran;
- Bailer, Robert T;
- Chambers, Michael;
- Chuang, Gwo-Yu;
- Doria-Rose, Nicole A;
- Druz, Aliaksandr
Publication type:
Article
The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.
Published in:
Nature Structural & Molecular Biology, 2013, v. 20, n. 2, p. 174, doi. 10.1038/nsmb.2472
By:
- Wang, Feng;
- Redding, Sy;
- Finkelstein, Ilya J;
- Gorman, Jason;
- Reichman, David R;
- Greene, Eric C
Publication type:
Article
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice.
Published in:
Nature Structural & Molecular Biology, 2010, v. 17, n. 8, p. 932, doi. 10.1038/nsmb.1858
By:
- Gorman, Jason;
- Plys, Aaron J.;
- Visnapuu, Mari-Liis;
- Alani, Eric;
- Greene, Eric C.
Publication type:
Article
Visualizing one-dimensional diffusion of proteins along DNA.
Published in:
Nature Structural & Molecular Biology, 2008, v. 15, n. 8, p. 768, doi. 10.1038/nsmb.1441
By:
- Gorman, Jason;
- Greene, Eric C.
Publication type:
Article
Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06424-6
By:
- Johnson, Erik L.;
- Doria-Rose, Nicole A.;
- Gorman, Jason;
- Bhiman, Jinal N.;
- Schramm, Chaim A.;
- Vu, Ashley Q.;
- Law, William H.;
- Zhang, Baoshan;
- Bekker, Valerie;
- Karim, Salim S. Abdool;
- Ippolito, Gregory C.;
- Morris, Lynn;
- Moore, Penny L.;
- Kwong, Peter D.;
- Mascola, John R.;
- Georgiou, George
Publication type:
Article
Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.
Published in:
PLoS Pathogens, 2019, v. 15, n. 9, p. 1, doi. 10.1371/journal.ppat.1008005
By:
- Sacks, David;
- Bhiman, Jinal N.;
- Wiehe, Kevin;
- Gorman, Jason;
- Kwong, Peter D.;
- Morris, Lynn;
- Moore, Penny L.
Publication type:
Article
Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes.
Published in:
PLoS Pathogens, 2019, v. 15, n. 4, p. 1, doi. 10.1371/journal.ppat.1007632
By:
- O’Brien, Sean P.;
- Swanstrom, Adrienne E.;
- Pegu, Amarendra;
- Ko, Sung-Youl;
- Immonen, Taina T.;
- Del Prete, Gregory Q.;
- Fennessey, Christine M.;
- Gorman, Jason;
- Foulds, Kathryn E.;
- Schmidt, Stephen D.;
- Doria-Rose, Nicole;
- Williamson, Carolyn;
- Hatziioannou, Theodora;
- Bieniasz, Paul D.;
- Li, Hui;
- Shaw, George M.;
- Mascola, John R.;
- Koup, Richard A.;
- Kwong, Peter D.;
- Lifson, Jeffrey D.
Publication type:
Article

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