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- Title
Disclosure of Amyloid Status for Risk of Alzheimer Disease to Cognitively Normal Research Participants With Subjective Cognitive Decline: A Longitudinal Study.
- Authors
Wake, Taisei; Tabuchi, Hajime; Funaki, Kei; Ito, Daisuke; Yamagata, Bun; Yoshizaki, Takahito; Nakahara, Tadaki; Jinzaki, Masahiro; Yoshimasu, Haruo; Tanahashi, Iori; Shimazaki, Hiroumi; Mimura, Masaru
- Abstract
This study aimed to investigate the long-term impacts of disclosing amyloid status for a risk of Alzheimer disease (AD) to cognitively normal research participants with subjective cognitive decline (SCD), which represents an initial manifestation of AD. Forty-two participants were classified as the amyloid-positive (n = 10) or amyloid-negative (n = 32) groups. We assessed symptoms of anxiety, depression, and test-related distress at 6, 24, and 52 weeks after results disclosure. No difference was found over time in anxiety, depression, and test-related distress in either group. Although no significant differences were observed between groups in anxiety or depression, the amyloid-negative group had a significantly higher level of test-related distress than the amyloid-positive group at 52 weeks. Disclosing amyloid status to cognitively healthy research participants with SCD did not cause significant long-term psychological risks. However, a theoretical spectrum of subjective concern may exist about cognitive decline in amyloid-negative individuals.
- Subjects
ALZHEIMER'S disease risk factors; AMYLOIDOSIS; ANXIETY; COGNITION disorders; MENTAL depression; LONGITUDINAL method; PSYCHOLOGICAL stress; DISCLOSURE; PSYCHOLOGY of human research subjects; DISEASE complications
- Publication
American Journal of Alzheimer's Disease & Other Dementias, 2020, Vol 35, p1
- ISSN
1533-3175
- Publication type
Article
- DOI
10.1177/1533317520904551