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- Title
SNX-2112, a Novel Hsp90 Inhibitor, Induces G2/M Cell Cycle Arrest and Apoptosis in MCF-7 Cells.
- Authors
Shao-Xiang WANG; Huai-Qiang Ju; Kai-Sheng Liu; Jia-Xuan ZHANG; Xiao WANG; Yang-Fei XIANG; Rui WANG; Jin-Yun Liu; Qiu-Ying Liu; Min XIA; Guo-Wen XING; Zhong LIU; Yi-Fei WANG
- Abstract
The article presents a study regarding the effects of SNX-2112 heat shock protein 90 (Hsp90) inhibitor on the inhibition of cell growth, apoptosis, and cycle in MCF-7 human breast cancer cells. The study indicate that the SNX-2112 inhibits cell growth in a dose- and time-dependent manner based on a 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay and flow cytometric analysis. The study has found the involve activation of mitochondrial apoptopic pathway in SNX-2112.
- Subjects
HEAT shock proteins; ENZYME inhibitors; CELL growth; APOPTOSIS; CELL cycle; BREAST cancer; CANCER cells; FLOW cytometry
- Publication
Bioscience, Biotechnology & Biochemistry, 2011, Vol 75, Issue 8, p1540
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.110225