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- Title
Neutralization of Burkholderia pseudomallei Protease by Fabs Generated through Phage Display.
- Authors
Nathan, Sheila; Rader, Christoph; Barbas, Carlos F.
- Abstract
The article describes the construction of a combinatorial mouse-human chimeric antibody fragment (Fab) antibody library targets against the protease of the tropical pathogen, Burkholderia pseudomallei. Restriction finger printing identifies the families of Fabs. Purified Fabs demonstrates the capability to inhibit Burkholderia pseudomallei protease activity. The Fab antibody become candidates for immunotherapy and tools to aid in elucidation.
- Subjects
NEUTRAL proteinases; PROTEOLYTIC enzymes; PATHOGENIC microorganisms; IMMUNOGLOBULINS; IMMUNOTHERAPY
- Publication
Bioscience, Biotechnology & Biochemistry, 2005, Vol 69, Issue 12, p2302
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.69.2302