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- Title
Hippocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase.
- Authors
Mir Sajad; Jamil Zargan; Raman Chawla; Sadiq Umar; Mir Sadaqat; Haider Khan
- Abstract
Abstract Experimental Autoimmune Encephalomyelitis (EAE) is a well-established animal model of human multiple sclerosis (MS). The effect of this inflammatory disease on hippocampus has not been addressed. Keeping in view the above consideration an attempt was made to delineate the effect of EAE on the hippocampus of Wistar rats. The assessment of the damage to the hippocampus was done 16 days post induction by the immunolocalization of ChAT (choline acetyl transferase). ChAT decreased remarkably after induction that revealed cholinergic neuronal degeneration in the hippocampus. Subsequently, many biochemical parameters were assessed to ascertain inflammatory activation of nitric oxide and associated oxidative damage as a putative mechanism of the cholinergic degeneration. Nitric oxide metabolites increased significantly (P P P P P P
- Subjects
NEURODEGENERATION; HIPPOCAMPUS (Brain); ALLERGIC encephalomyelitis; MULTIPLE sclerosis; PARASYMPATHOMIMETIC agents; NITRIC oxide; PEROXIDASE; PATIENTS
- Publication
Molecular & Cellular Biochemistry, 2009, Vol 328, Issue 1/2, p183
- ISSN
0300-8177
- Publication type
Article
- DOI
10.1007/s11010-009-0088-3