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- Title
The relationship of periodontal disease severity to serum and GCF substance P levels in diabetics.
- Authors
Ozturk, Ayla; Bilgici, Birşen; Odyakmaz, Selcen; Konas, Elif
- Abstract
Objective: To compare circulating and gingival crevicular fluid (GCF) substance P concentrations in well- and poorly controlled type 2 diabetic patients with chronic periodontitis. Method and Materials: Forty-five serum and 90 GCF samples were collected from diabetic patients with periodontal disease, and the concentrations of substance P were quantified by radioimmunoassay. Results: Serum substance P levels were higher in the poorly controlled diabetic group than in patients with good glycemic control (P = .01); within the poorly controlled group, patients with severe attachment levels had the highest circulating substance P levels (P = .02). Additionally, the diseased sites showed higher substance P levels than control sites (P = .0016). The GCF substance P concentrations in diseased sites correlated significantly with clinical findings such as Plaque Index (r = 0.51, P = .001) and bleeding on probing (r = 0.35, P = .029). Conclusion: Within the limits of this study, our preliminary findings indicate that periodontal inflammation may influence circulating and GCF substance P levels in poorly controlled diabetic subjects.
- Subjects
TURKEY; PERIODONTAL disease diagnosis; PERIODONTITIS; BLOOD serum analysis; CHI-squared test; STATISTICAL correlation; DEMOGRAPHY; MOUTH; NEUROPEPTIDES; TYPE 2 diabetes; RADIOIMMUNOASSAY; SMOKING; T-test (Statistics); SAMPLE size (Statistics); DATA analysis software; DESCRIPTIVE statistics; DIAGNOSIS
- Publication
Quintessence International, 2012, Vol 43, Issue 7, p587
- ISSN
0033-6572
- Publication type
Article