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- Title
Combined quantitative dynamic contrast-enhanced MR imaging and <sup>1</sup>H MR spectroscopic imaging of human prostate cancer.
- Authors
van Dorsten, Ferdinand A.; van der Graaf, Marinette; Engelbrecht, Marc R.W.; van Leenders, Geert J.L.H.; Verhofstad, Albert; Rijpkema, Mark; de la Rosette, Jean J.M.C.H.; Barentsz, Jelle O.; Heerschap, Arend
- Abstract
Purpose To differentiate prostate carcinoma from healthy peripheral zone and central gland using quantitative dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging and two-dimensional 1H MR spectroscopic imaging (MRSI) combined into one clinical protocol. Materials and Methods Twenty-three prostate cancer patients were studied with a combined DCE-MRI and MRSI protocol. Cancer regions were localized by histopathology of whole mount sections after radical prostatectomy. Pharmacokinetic modeling parameters, Ktrans and kep, as well as the relative levels of the prostate metabolites citrate, choline, and creatine, were determined in cancer, healthy peripheral zone (PZ), and in central gland (CG). Results Ktrans and kep were higher ( P < 0.05) in cancer and in CG than in normal PZ. The (choline + creatine)/citrate ratio was elevated in cancer compared to the PZ and CG (P < 0.05). While a (choline + creatine)/citrate ratio above 0.68 was found to be a reliable indicator of cancer, elevated Ktrans was only a reliable cancer indicator in the diagnosis of individual patients. Ktrans and (choline + creatine)/citrate ratios in cancer were poorly correlated (Pearson r2 = 0.07), and thus microvascular and metabolic abnormalities may have complementary value in cancer diagnosis. Conclusion The combination of high-resolution spatio-vascular information from dynamic MRI and metabolic information from MRSI has excellent potential for improved localization and characterization of prostate cancer in a clinical setting. J. Magn. Reson. Imaging 2004;20:279-287. © 2004 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2004, Vol 20, Issue 2, p279
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.20113