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- Title
Mechanical Stress on Lysozyme Crystals during Dynamic Cross-Flow Filtration.
- Authors
Cornehl, B.; Grünke, T.; Nirschl, H.
- Abstract
The influence of mechanical stress on the crystal size distribution of lysozyme crystal slurries in a dynamic cross-flow device is discussed. The reduction of crystal size may have an influence on mass and resistance of the fouling layer. A filter test device with a filter area of 130 cm2 is used for thickening. After thickening, a model impurity, namely bovine serum albumin, is washed out of the suspension. A reduction of crystal size due to stirring and a reduced fouling layer with increasing stirrer speed is observed. Furthermore, a higher stirring speed increases the specific filtrate flux. In the presence of the impurity, more crystal aggregates than single isometric crystals are formed and, hence, the decrease of crystal size due to shear forces is more pronounced than without impurity.
- Subjects
LYSOZYME crystallography; FILTERS &; filtration; FOULING; STRAINS &; stresses (Mechanics); CROSS-flow reactors
- Publication
Chemical Engineering & Technology, 2013, Vol 36, Issue 10, p1665
- ISSN
0930-7516
- Publication type
Article
- DOI
10.1002/ceat.201300178