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- Title
Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK.
- Authors
Oulès, Bénédicte; Mourah, Samia; Baroudjian, Barouyr; Jouenne, Fanélie; Delyon, Julie; Louveau, Baptiste; Gruber, Aurélia; Lebbé, Céleste; Battistella, Maxime
- Abstract
Wnt/β-catenin signaling plays crucial roles in melanocyte biology and may be implicated in melanoma progression. In this study, we retrospectively examined a real-life cohort of melanomas mutated for β-catenin (CTNNB1), in association or not with a MAPK mutation (of BRAF or NRAS), and analyzed their clinical, histopathological, and molecular characteristics. Our results indicate that, regardless of the presence of a concurrent MAPK mutation, CTNNB1mut cutaneous primary melanomas display more proliferative hallmarks (increased Breslow thickness, mitotic index, and ulceration) than their CTNNB1 wild-type counterparts. Accordingly, they often progress to the metastatic stage. Furthermore, concurrent CTNNB1 and MAPK mutations do not necessarily confer a deep penetrating nevi phenotype. Altogether, this study provides evidence that CTNNB1 mutations in melanomas are associated with specific clinical and pathological features.
- Subjects
MELANOMA prognosis; GENETIC mutation; NEVUS; MELANOMA; CYTOSKELETAL proteins; RETROSPECTIVE studies; COMPARATIVE studies
- Publication
Virchows Archiv: European Journal of Pathology, 2022, Vol 480, Issue 2, p475
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-021-03119-0