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- Title
Nonlinear optical interference of two successive coherent anti-Stokes Raman scattering signals for biological imaging applications.
- Authors
Eun Seong Lee; Jae Yong Lee; Yong Shim Yoo
- Abstract
The nonlinear optical interference of two successively generated coherent anti-Stokes Raman scattering (CARS) signals from two different samples placed in series is demonstrated for the imaging performance, in which a collinear phase matching geometry is used. The relative phase of two CARS signals is controlled by a phase-shifting unit made of dispersive glass materials of which the thickness can be precisely varied. The clear interference fringes are observed as the thickness of the phase-shifting unit changes. The interference effect is then utilized to achieve a better quality CARS image of a biological tissue taken from a mouse skin. Placing the tissue in the second sample position and performing raster scans of the laser beams on it, we can acquire a CARS image of higher contrast compared to the normal image obtained without interferometric implementation.
- Subjects
IMAGING systems in biology; MICROBIAL imaging; RAMAN spectroscopy; LASER beams
- Publication
Journal of Biomedical Optics, 2007, Vol 12, Issue 2, p24010
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.2718560