We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Novel putative pathogenic viruses identified in pangolins by mining metagenomic data.
- Authors
Ning, Songyi; Dai, Ziyuan; Zhao, Chunyan; Feng, Zhanghao; Jin, Kexin; Yang, Shixing; Shen, Quan; Wang, Xiaochun; Sun, Runfeng; Zhang, Wen
- Abstract
The pangolin is the only scaly mammal in the world and also an important reservoir of pathogenic viruses. Habitat loss and poaching have been shrinking the survival range of pangolins. More information on pangolin virus populations is needed to better understand and assess potential disease risks. In this study, viral metagenomic data were used to reinvestigate the virome in pangolin lung tissue. Complete genome sequences of two novel anelloviruses were acquired and clustered with the referenced feline strains belonging to genus Tettorquevirus and genus Etatorquevirus, respectively. Two genomes belonging to the genus Gemykibivirus, and species Bat‐associated cyclovirus 9 were detected, respectively. One genome with a large contig belonging to the genus Senecavirus were also characterized, according to phylogenetic analysis, which can be presumed to be a novel species. In addition, a full genome of endogenous retroviruse (ERV) was assembled from the lungs of pangolin, and this virus may have the possibility of cross‐species transmission during the evolution. This virological investigation has increased our understanding of the virome carried by pangolins and provided a reference baseline for possible zoonotic infectious diseases in the future. Highlights: Genomes of six potential pathogenic viruses were acquired from next‐generation sequencing data of the lung tissue of pangolins.Phylogenetic analysis showed these viruses belonged to the families of Anelloviridae, Circoviridae, Genomoviridae, Picornaviridae, and Retroviridae, respectively.Genetic analysis revealed that some viruses from pangolins have the potential for cross‐species transmission during evolution.
- Subjects
PATHOGENIC viruses; DATA mining; PANGOLINS; WHOLE genome sequencing; ZOONOSES
- Publication
Journal of Medical Virology, 2022, Vol 94, Issue 6, p2500
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.27564