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- Title
CYP2C19 genetics in fatal carisoprodol intoxications.
- Authors
Høiseth, Gudrun; Majid, Umair; Mørland, Jørg; Bramness, Jørgen; Molden, Espen
- Abstract
Introduction: Carisoprodol, a frequently used muscle relaxant, can cause potentially fatal intoxications. Conversion to its active metabolite meprobamate is almost solely mediated by cytochrome P450 2C19 (CYP2C19), and mutations in this enzyme could have significant effects on serum concentrations. The objective of this study was to investigate the role of CYP2C19 genetics in mortalities due to carisoprodol intoxication. Methods: The frequencies of CYP2C19 variant alleles were compared between the study group ( n = 75) and two control groups, i.e. (1) deaths where carisoprodol was detected in the blood of the deceased, but intoxication was not the cause of death (control group A, n = 38), and (2) a healthy population not using carisoprodol (control group B, n = 185). In the study group and control A, the concentrations of carisoprodol and meprobamate were compared between the different genotype subgroups. Results: The variant allele frequencies of CYP2C19 did not differ significantly between the study group and control groups. Moreover, no statistically significant difference in the concentrations of carisoprodol and meprobamate between the different genotype subgroups was found. Conclusions: This study finds no evidence for an important association between CYP2C19 genetics and mortality risk of carisoprodol. Other factors, such as co-administration with other drugs, likely play a more important role.
- Subjects
NORWAY; MORTALITY risk factors; ALLELES; CONFIDENCE intervals; DRUG toxicity; EPIDEMIOLOGY; GENES; GENETIC polymorphisms; MUSCLE relaxants; STATISTICS; DATA analysis; ACYCLIC acids; DATA analysis software
- Publication
European Journal of Clinical Pharmacology, 2012, Vol 68, Issue 11, p1561
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-012-1278-6