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- Title
Comparison of Treatment Results of Rheumatoid Arthritis with Biological Agents and Disease-Modifying Anti-Rheumatic Drugs.
- Authors
ELİBÜYÜK, Sümeyra; AYDIN, Teoman
- Abstract
Introduction: Rheumatoid arthritis (RA) is a systemic, inflammatory, and autoimmune disease characterized by polyarthritis. Although its etiology is not fully known, genetic and environmental factors are emphasized. RA causes symmetric inflammatory synovitis in peripheral joints. In the later stages of the disease, inflammation is followed by cartilage damage, bone erosion, and deterioration in joint integrity. As the disease progresses, disability and shortened life span may occur. Method: In our study, 28 patients between the ages of 18 and 65 years who were diagnosed with RA and received treatment for at least 6 months were included by retrospectively examining their files. Patients were divided into two groups. The first group consists of 39 people who use only disease-modifying antirheumatic drugs (DMARDs). The second group consisted of 39 people treated with biological agents. Laboratory results [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF)] of the patients at the first examination and 6th month follow-up were recorded from their files and analyzed to compare the effect of different drug groups on prognosis. Results: The average age of patients using biological agents and using DMARDs are 50.27±7.9, respectively, and was calculated as 46.79±8.6. Treatment between groups among the parameters examined and a statistically significant difference was detected. The pre- and post-treatment parameters examined in both groups decreases, but this decrease does not occur with combined anti-tumor necrosis factor statistically higher in the group receiving treatment than in the DMARD group was found to be significant. At the 6th month followup between both groups, ESR, RF, and CRP values were examined and a statistically significant difference was detected (p<0.001). Conclusion: Disease activity of biological agents compared with DMARDs was found to be statistically more effective in reducing disease activity.
- Subjects
SYNOVITIS; ANTIRHEUMATIC agents; RHEUMATOID arthritis; BLOOD sedimentation; RHEUMATOID factor; C-reactive protein; AUTOIMMUNE diseases
- Publication
Bezmialem Science, 2024, Vol 13, pS50
- ISSN
2148-2373
- Publication type
Abstract