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- Title
Fetoscopy in the pregnant rabbit at midgestation.
- Authors
Papadopulos, Nikolaos A.; Dumitrascu, Irina; Ordoñez, Jose L.; Decaluwé, Herbert; Lerut, Toni E.; Barki, Gerard; Deprest, Jan A.; Papadopulos, N A; Dumitrascu, I; Ordoñez, J L; Decaluwé, H; Lerut, T E; Barki, G; Deprest, J A
- Abstract
<bold>Objective: </bold>To develop a small animal model for fetoscopy.<bold>Methods: </bold>In 12 time-dated pregnant rabbits at 22 days' gestational age (term 32 days) one amniotic sac in each uterine horn (n = 24) was used for a fetoscopic procedure. After laparotomy, a 2- to 3-mm microsurgical myometrial incision was made to expose the chorionic and amniotic membrane. Under microscopic control, a 2-mm needle was inserted into the amniotic sac. Through this a 1.2-mm endoscope was passed to carry out fetoscopy during maximally 10 min, using 5-10 ml saline amnioinfusion. Mean outcome measurements were ability to visualize the placenta, umbilical cord and the different fetal elements during fetoscopy, as well as fetal survival and weight at second-look operation at 30 days. The untreated amniotic sacs served as negative controls.<bold>Results: </bold>In all cases, fetoscopy could be carried out successfully, and all fetuses survived till delivery without significant influence on fetal birth weight.<bold>Conclusion: </bold>The midgestational rabbit can be used to perform fetoscopy.
- Subjects
AMNION; AMNIOTIC liquid; ANIMAL experimentation; BIOLOGICAL models; BIRTH weight; COMPARATIVE studies; FETOSCOPY; GESTATIONAL age; RESEARCH methodology; MEDICAL cooperation; PREGNANCY complications; RABBITS; RESEARCH; EVALUATION research
- Publication
Fetal Diagnosis & Therapy, 1999, Vol 14, Issue 2, p118
- ISSN
1015-3837
- Publication type
journal article
- DOI
10.1159/000020902