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- Title
Functional identity between murine γ Interferon and macrophage activating factor.
- Authors
Schultz, Richard M.; Kleinschmidt, Walter J.
- Abstract
We have previously suggested that two lymphokine activities-macrophage activating factor (MAF) and γ interferon (IFN-γ)-are mediated by the same molecule1,2. Striking similarities were noted in their cellular biosynthesis, rate of inactivation with acid treatment and heating, and elution profiles on Sepha-cryl S-200. In addition, highly specific polyclonal antibodies to murine IFN-γ neutralized MAF and IFN-γ to a similar degree. However, definitive studies require a pure product and we now report that murine IFN-γ that had been cloned and expressed in a simian nonlymphoid cell line shows MAF activity. But it is not yet known whether IFN-γ is responsible for all the MAF activity in media conditioned by T cells as the possibility for MAF heterogeneity remains.
- Publication
Nature, 1983, Vol 305, Issue 5931, p239
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/305239a0