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- Title
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing.
- Authors
Haltenhof, Tom; Preußner, Marco; Heyd, Florian
- Abstract
Temperature-dependent alternative splicing (AS) is a crucial mechanism for organisms to adapt to varying environmental temperatures. In mammals, even slight fluctuations in body temperature are sufficient to drive significant AS changes in a concerted manner. This dynamic regulation allows organisms to finely tune gene expression and protein isoform diversity in response to temperature cues, ensuring proper cellular function and physiological adaptation. Understanding the molecular mechanisms underlying temperature-dependent AS thus provides valuable insights into the intricate interplay between environmental stimuli and gene expression regulation. In this review, we provide an overview of recent advances in understanding temperature-regulated AS across various biological processes and systems. We will discuss the machinery sensing and translating temperature cues into changed AS patterns, the adaptation of the splicing regulatory machinery to extreme temperatures, the role of temperature-dependent AS in shaping the transcriptome, functional implications and the development of potential therapeutics targeting temperature-sensitive AS pathways.
- Subjects
GENETIC regulation; ALTERNATIVE RNA splicing; BIOLOGICAL systems; PHYSIOLOGICAL adaptation; GENE expression; BODY temperature regulation
- Publication
Biochemical Journal, 2024, Vol 481, Issue 15, p999
- ISSN
0264-6021
- Publication type
Article
- DOI
10.1042/bcj20230410