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- Title
Cytotoxic Diterpenoid Alkaloids from Aconitum austroyunnanense.
- Authors
Hu, Jiang; Li, Guofen; Xu, Fengming; Mao, Xia; Peng, Tianfeng; Jin, Nianhua; Yin, Si; Gao, Feng
- Abstract
A phytochemical investigation on the roots of Aconitum austroyunnanense led to the isolation of two previously undescribed diterpenoid alkaloids, austroyunnanines D and E (1 and 2). Their structures were determined by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, NOESY, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activity against three human gastric carcinoma cell lines. As a result, compound 1 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 values less than 20.0 μM.
- Subjects
MONKSHOODS; STOMACH cancer; MASS spectrometry; CELL lines; CYTOTOXINS; NUCLEAR magnetic resonance spectroscopy
- Publication
Chemistry of Natural Compounds, 2024, Vol 60, Issue 3, p472
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-024-04354-y