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- Title
Do NHE inhibition and ischemic preconditioning convey cardioprotection through a common mechanism?
- Authors
Gumina, Richard J.; Terzic, Andre; Gross, Garrett J.
- Abstract
The article reports that with myocardial ischemia, mitochondrial ATP production ceases and glycolysis results in an accumulation of lactate and intracellular hydrogen. With continued ischemia, the sodium/hydrogen exchanger (NHE) has been reported to that may exceed intracellular acidosis within 10-20 minutes. With reperfusion, the rapid washout of extracellular hydrogen reactivates the NHE resulting in an increase in intracellular sodium. Thus decrease in acidosis has been associated with an attenuation and delay of the rise in intracellular calcium that occurs during sustained ischemia.
- Subjects
CORONARY disease; MITOCHONDRIA; ADENOSINE triphosphate; GLYCOLYSIS; ACIDOSIS; ISCHEMIA
- Publication
Basic Research in Cardiology, 2001, Vol 96, Issue 4, p318
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s003950170039