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- Title
Translating NIA‐AA criteria into usual practice: Report from the ReDeMa Project.
- Authors
Sánchez‐Soblechero, Antonio; Berbel, Angel; Villarejo, Alberto; Palmí‐Cortés, Itziar; Vieira, Alba; Gil‐Moreno, María José; Fernández, Cristina; Martín‐Montes, Ãngel; Carreras, María Teresa; Fernández, Yolanda; Puertas, Carolina; Blanco‐Palmero, Victor; Llamas, Sara; González‐Sánchez, Marta; Lapeña, Teresa; de Luis, Pilar; Manzano, Sagrario; Olazarán, Javier
- Abstract
INTRODUCTION: Biomarker‐informed criteria were proposed for the diagnosis of Alzheimer's disease (AD) by the National Institute on Aging and the Alzheimer's Association (NIA‐AA) in 2011; however, the adequacy of this criteria has not been sufficiently evaluated. METHODS: ReDeMa (Red de Demencias de Madrid) is a regional cohort of patients attending memory and neurology clinics. Core cerebrospinal fluid biomarkers were obtained, NIA‐AA diagnostic criteria were considered, and changes in diagnosis and management were evaluated. RESULTS: A total of 233 patients were analyzed (mean age 70 years, 50% women, 73% AD). The diagnostic language was modified significantly, with a majority assumption of NIA‐AA definitions (69%). Confidence in diagnosis increased from 70% to 92% (p < 0.0005) and management was changed in 71% of patient/caregivers. The influence of neurologist's age or expertise on study results was minimal. DISCUSSION: The NIA‐AA criteria are adequate and utile for usual practice in memory and neurology clinics, improving diagnostic confidence and significantly modifying patient management. HIGHLIGHTS: Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers increase diagnostic certainty regardless of the neurologist.AD CSF biomarkers lead to changes in disease management.Biomarker‐enriched, 2011 NIA‐AA diagnostic criteria are adequate for usual practice.
- Subjects
ALZHEIMER'S disease; CEREBROSPINAL fluid; TUBERCULOUS meningitis
- Publication
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2024, Vol 10, Issue 1, p1
- ISSN
2352-8737
- Publication type
Article
- DOI
10.1002/trc2.12451