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- Title
SIRT3 Modulates Endothelial Mitochondrial Redox State during Insulin Resistance.
- Authors
Martino, Elisa; Balestrieri, Anna; Anastasio, Camilla; Maione, Martina; Mele, Luigi; Cautela, Domenico; Campanile, Giuseppe; Balestrieri, Maria Luisa; D'Onofrio, Nunzia
- Abstract
As for pyroptosis, the PA-induced lysosome accumulation and autophagy ( I p i < 0.001) was reduced in SIRT3 SP + sp +PA cells ( I p i < 0.01 vs. mimic NC+PA) (Figure 6). Results showed that pyroptosis induced by PA ( I p i < 0.001) was reverted in SIRT3 SP + sp +PA ( I p i < 0.01 vs. mimic NC+PA) (Figure 5A-C). Representative images by fluorescence microscopy and flow cytometry analysis of (A-C) pyroptosis and (D-F) autophagy, expressed as green median fluorescence ± SD (n = 3), in EC exposed for 48 h to 0.5 mM VB, 0.5 mM PA (PA), or pretreated for 16 h with VB before 48 h PA treatment ( VB + PA).
- Subjects
INSULIN receptors; BETAINE; INSULIN resistance; MITOCHONDRIA; NANOTECHNOLOGY; LIFE sciences; CYTOLOGY
- Publication
Antioxidants, 2022, Vol 11, Issue 8, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11081611