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- Title
Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery.
- Authors
BAL ÖZTÜRK, Ayça; OĞUZ, Nesrin; TEKARSLAN ŞAHİN, Hande; EMİK, Serkan; ALARÇİN, Emine
- Abstract
An amphiphilic core/shell-type polymer-based drug carrier system (HPAE-PCL-b-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-b-poly(ε-caprolactone) diblock polymers (MPEG-b-PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, ´H NMR, 13C NMR, and GPC analysis. Monodisperse HPAE-PCL-b- MPEG nanoparticles with dimensions of <200 nm and polydispersity index of <0.5 were prepared by nanoprecipitation method and characterized with SEM, particle size, and zeta potential analysis. 5-Fluorouracil was encapsulated within HPAE-PCL-b-MPEG nanoparticles. In vitro drug release profiles and cytotoxicity of blank and 5-fluorouracil-loaded nanoparticles were examined against the human colon cancer HCT116 cell line. All results suggest that HPAE-PCL-b-MPEG nanoparticles offer an alternative and effective drug nanocarrier system for drug delivery applications.
- Subjects
DRUG delivery systems; DRUG carriers; ZETA potential; ETHYLENE glycol; COLON cancer; NANOPARTICLES
- Publication
Turkish Journal of Chemistry, 2020, Vol 44, Issue 2, p518
- ISSN
1300-0527
- Publication type
Article
- DOI
10.3906/kim-1910-35