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- Title
Cardiac Dysfunction and Exercise Tolerance in Patients after Complex Treatment for Cranial and Craniospinal Tumors in Childhood.
- Authors
Novikova, Alena; Poltavskaya, Maria; Pavlova, Maria; Chomakhidze, Petr; Bykova, Aleksandra; Potemkina, Nadezhda; Chashkina, Maria; Fashafsha, Zaki Z. A.; Mesitskaya, Dinara; Gogiberidze, Nana; Levshina, Anna; Giverts, Ilya; Shchekochikhin, Dmitry; Andreev, Denis
- Abstract
State-of-the-art therapy improves the five-year survival rate of patients under the age of 20 with cranial and craniospinal tumors by up to 74%. The urgency of dealing effectively with late treatment-associated cardiovascular complications is rising. Objective: We aimed to assess echocardiographic parameters and exercise performance in subjects with a history of complex treatment for cranial and craniospinal tumors in childhood. Methods: the study of 48 subjects who underwent cranial and craniospinal irradiation for CNS tumors in childhood and 20 healthy age- and sex-matched volunteers was conducted. The examination included hormone studies, cardiopulmonary exercise testing, and, in the main group, echocardiography (ECHO). Results: In five (10.4%) patients, ECHO changes were detected after complex anti-cancer treatment: thickening and calcification of the aortic valve leaflets (2%), and reduction in the systolic LV and RV function (8% and 6%, respectively). Irradiation of various areas was a significant predictor for reduced exercise tolerance, hyperventilation at rest and upon exertion, and an increased ventilatory equivalent for carbon dioxide. Low exercise tolerance was associated with a younger age at the time of treatment initiation. Significant differences were noted between the control group and the childhood cancer survivors with endocrine disorders. Conclusions: The obtained data confirm the importance of regular cardiovascular and endocrine monitoring of this group of cancer survivors.
- Subjects
EXERCISE tolerance; HYPERVENTILATION; HEART diseases; EXERCISE tests; ENDOCRINE diseases; TUMORS
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 11, p3045
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13113045