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- Title
经尿道输尿管镜钬激光碎石术后尿路感染的影响因素及其对患者细胞免疫功能和生活质量的影响.
- Authors
孙家各; 孙博; 侯备; 郭辉; 刘川海; 张晓毅
- Abstract
Objective: To investigate the influence factors of urinary tract infection after transurethral ureteroscopic holmium laser lithotripsy and their effects on cellular immune function and quality of life. Methods: 150 patients who received transurethral ureteroscopic holmium laser lithotripsy in our hospital from June 2019 to January 2021 were selected. T lymphocyte subsets were detected by flow cytometry: CD4+and CD8+, CD4+/CD8+were calculated. The quality of life of the patients was evaluated by 36-item short form of life health scale(SF-36) before and after operation. Urinary tract infection after transurethral holmium laser lithotripsy were analyzed.Results: Among the 150 patients, 18 had urinary tract infection after operation, and the incidence was 12.00%(18/150). According to whether there was urinary tract infection, they were divided into infected group(n=18) and uninfected group(n=132). Univariate analysis showed that urinary tract infection after urethra holmium laser lithotripsy were related to stone diameter, age, diabetes mellitus, length of stay, prophylactic use of antibiotics, residual stones, operation time, and double J tube indwelling time(P<0.05). The results of multivariate Logistic regression analysis showed that: age 61~ years, stones diameter ≧2 cm, double J catheter indwelling time≧14 d,operation time ≧2 h, with residual stones, complicated with diabetes mellitus were risk factors for postoperative urinary tract infection,and preventive application of antibiotics was a protective factor(P<0.05). CD4+and CD4+/CD8+decreased in the two groups after operation, but the uninfected group was higher than the infected group. CD8+increased, but the uninfected group was lower than the infected group(P<0.05). The scores of mental health, general health, social function, emotional function, vitality, physical pain,physiological function, physiological function increased in the two groups, and the uninfected group was higher than the infected group(P<0.05). Conclusion: After transurethral ureteroscopic holmium laser lithotripsy, the cellular immune function and quality of life of patients with urinary tract infection decrease, and their urinary tract infection is affected by age, stone diameter, operation time and other factors. The preventive application of antibiotics can reduce the risk of urinary tract infection.
- Subjects
LASER lithotripsy; URINARY tract infections; PREOPERATIVE risk factors; IMPLANTABLE catheters; LYMPHOCYTE subsets; LOGISTIC regression analysis
- Publication
Progress in Modern Biomedicine, 2022, Vol 22, Issue 14, p2686
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2022.14.017