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- Title
Immunohistochemical expression of CD117 in borderline, low- and high-grade ovarian surface epithelial tumours: A clinicopathological study.
- Authors
AL-SHAMI, Samar A.; AL-KAABI, Methaq Mueen; MAHDI, Ahmed K.; AL-ATTAR, Zaid
- Abstract
Introduction: Ovarian cancer is one of leading causes of cancer related death in gynecology. CD117 is a tyrosine kinase receptor that plays an important role in regulation of apoptosis, cell proliferation and adhesion by binding to its ligand-stem cell factor. Recent studies demonstrated its aberrant overexpression in various malignancies and concluded that it may play a pivotal role in carcinogenesis. Aim: To evaluate CD117 expression in ovarian surface epithelial tumours. Materials and Methods: This retrospective study included 30 ovarian epithelial borderline, low and highly malignant tumours' formalin-fixed paraffin-blocks (FFPE) tissue blocks. Tissue sections were subjected to the routine haematoxylin-eosin stain and with the anti-CD117 immunohistochemically. Results: There is a high significant difference in CD117 expression between borderline and malignant groups (P = 0.001). Additionally, there was significant difference in expression in relation to histopathological type (serous versus non-serous) in low-grade and the high-grade ovarian surface epithelial tumours (p=0.04, p=0.035 respectively). Tumour grade and stage strongly correlates with CD117 expression (p=0.014, p=0.019 respectively). Conclusion: We concluded that CD117 expression was significantly correlated with higher ovarian tumour grade and stage.
- Subjects
EPHRIN receptors; PROTEIN-tyrosine kinases; TUMORS; CLINICAL pathology
- Publication
Malaysian Journal of Pathology, 2023, Vol 45, Issue 2, p229
- ISSN
0126-8635
- Publication type
Article