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- Title
Oxygen-dependent energy deficit as related to the problems of disorders of human ontogenetic development and sociobiological adaptation (theoretical and applied aspects).
- Authors
Ilyukhina, V.; Kataeva, G.; Korotkov, A.; Chernysheva, E.
- Abstract
The review states and argues theoretical propositions on the pathogenetic role of pre- and perinatal hypoxic-ischemic brain damage in the formation of sustained oxygen-dependent energy deficit underlying in later ontogenesis the following neurobiological abnormalities: (a) decline in the level of health and compensatory-adaptive abilities of an organism, (b) disorders of the psycho-speech development and adaptive behavior in children, (c) early development of neuropsychic diseases, (d) addition of other types of brain energy metabolism (including glucose metabolism) disorders in chronic polyetiologic diseases in young and middle-aged individuals. We highlight and theoretically substantiate the integrated physiological parameters of the oxygen-dependent energy deficit types. We address the features of abnormalities in neuroreflectory and neurohumoral regulatory mechanisms of the wakefulness level and its vegetative and hemodynamic provision in different types of energy deficit in children with DSMD, ADHD and school maladjustment. The use of the state-of-the-art neuroimaging techniques significantly increased the possibility of studying the relationship between the topical brain energy metabolism disorders and the peculiarities of disintegration of regulatory processes and cognitive functions in children with psycho-speech delays and in a wide range of chronic polyetiologic diseases.
- Subjects
BRAIN damage; SOCIOBIOLOGY; HYPOXEMIA; BRAIN imaging; ATTENTION-deficit hyperactivity disorder; CHILDREN with attention-deficit hyperactivity disorder; ADJUSTMENT disorders in children
- Publication
Journal of Evolutionary Biochemistry & Physiology, 2015, Vol 51, Issue 2, p85
- ISSN
0022-0930
- Publication type
Article
- DOI
10.1134/S0022093015020015