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- Title
The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO<sub>2</sub>.
- Authors
Ruffault, Pierre-Louis; Hayes, John A.; Autran, Sandra; Fortin, Gilles; Nomaksteinsky, Marc; Brunet, Jean-François; Goridis, Christo; D'Autréaux, Fabien; Hoshino, Mikio; Fujiyama, Tomoyuki; Kiehn, Ole; Hägglund, Martin
- Abstract
The article talks about the CO2 and H+ concentrations in the arterial blood. The key element of this circuitry is the retrotrapezoid nucleus (RTN) that is activated by increased CO2 or low pH and project to the respiratory rhythm generator. Here, intersectional genetic strategies to lesion the RTN neurons defined by Atoh1 and Phox2b expression. Glutamatergic transmission in cells curtails the phrenic nerve response to low pH.
- Subjects
BLOOD pH; EXCITATORY amino acid agents; NEURONS; PHRENIC nerve; EMBRYOLOGY
- Publication
eLife, 2015, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.07051