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- Title
Phenotypic complementation of genetic immunodeiciency by chronic herpesvirus infection.
- Authors
MacDuff, Donna A.; Reese, Tiffany A.; Kimmey, Jacqueline M.; Weiss, Leslie A.; Song, Christina; Xin Zhang; Kambal, Amal; Duan, Erning; Carrero, Javier A.; Boisson, Bertrand; Laplantine, Emmanuel; Israel, Alain; Picard, Capucine; Colonna, Marco; Edelson, Brian T.; Sibley, L. David; Stallings, Christina L.; Casanova, Jean-Laurent; Kazuhiro Iwai; Virgin, Herbert W.
- Abstract
The article explores how barrier-raised HOIL-1-deficient mice demonstrates amylopectin-like deposits in the myocardium but exhibits minimal signs of hyper-inflammation. Topics discussed include the variation in the presentation of hereditary immunodeficiencies explained by genetic or environmental factors and individuals with mutations in HOIL1 exhibiting amylopectinosis-linked myopathy with or without hyper-inflammation and immunodeficiency.
- Subjects
LABORATORY mice; AMYLOPECTIN; MYOCARDIUM; IMMUNODEFICIENCY; GENETIC mutation
- Publication
eLife, 2015, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.04494.001