We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sérový amyloid A a jeho klinický význam.
- Authors
K., Vilímová; O., Michnová; P., Kušnierová
- Abstract
Serum amyloid A (SAA) is one of the acute phase reactants. Its concentration in the organism rises in response to various stimuli, whether of infectious or non-infectious origin. SAA is an apolipoprotein that interacts with HDL, promotes the accumulation of leukocytes at the site of inflammation and the adhesion of platelets and participates in the removal of damaged cell membranes. SAA is water-insoluble, as is its precursor protein, which forms amyloid A deposits in various organs. Although the SAA value drops back to the minimum value after the reaction subsides, the organism no longer removes the amyloid A deposits from the tissues. Accumulation of amyloid in tissues results in their damage and limitation of function, and in the worst cases, leads to their failure. The formation of deposits in the tissues of organs is the basis of disease called amyloidosis.
- Subjects
ACUTE phase proteins; PROTEIN precursors; AMYLOID plaque; AMYLOID; AMYLOIDOSIS
- Publication
Klinická Biochemie a Metabolismus, 2022, Vol 30, Issue 4, p111
- ISSN
1210-7921
- Publication type
Article