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- Title
A Randomized Trial of Lorcaserin and Lifestyle Counseling for Maintaining Weight Loss Achieved with a Low-Calorie Diet.
- Authors
Shaw Tronieri, Jena; Wadden, Thomas A.; Berkowitz, Robert I.; Chao, Ariana M.; Pearl, Rebecca L.; Alamuddin, Naji; Leonard, Sharon M.; Carvajal, Ray; Bakizada, Zayna M.; Pinkasavage, Emilie; Gruber, Kathryn A.; Walsh, Olivia A.; Alfaris, Nasreen
- Abstract
<bold>Objective: </bold>Improving the maintenance of lost weight remains a critical challenge, which can be addressed by long-term behavioral and/or pharmacological interventions.<bold>Methods: </bold>This study investigated the efficacy of combined behavioral and pharmacological treatment in facilitating weight loss maintenance (WLM) in 137 adults (86.1% female; 68.6% black; BMI = 37.0 ± 5.6 kg/m2 ) who had lost ≥ 5% of initial weight during a 14-week low-calorie diet (LCD) program (mean = 9.3 ± 2.9%). Participants were randomly assigned to lorcaserin (10 mg twice a day) or placebo and were provided 16 group WLM counseling sessions over 52 weeks.<bold>Results: </bold>At 24 weeks post randomization, more lorcaserin-treated than placebo-treated participants maintained a ≥ 5% loss (73.9% vs. 57.4%; P = 0.033), and the lorcaserin-treated participants lost an additional 2.4 ± 0.8 kg versus a 0.6 ± 0.8 kg gain for placebo (P = 0.010). However, at week 52, groups did not differ on either co-primary outcome; 55.1% and 42.6%, respectively, maintained ≥ 5% loss (P = 0.110), with gains from randomization of 2.0 ± 0.8 kg and 2.5 ± 0.8 kg (P = 0.630), respectively. From the start of the LCD, groups maintained reductions of 7.8% and 6.6%, respectively (P = 0.318).<bold>Conclusions: </bold>Combined behavioral and pharmacological treatment produced clinically meaningful long-term weight loss in this group of predominantly black participants. Lorcaserin initially improved upon weight loss achieved with WLM counseling, but this advantage was not maintained at 1 year.
- Subjects
RANDOMIZED controlled trials; WEIGHT loss; PLACEBOS; RANDOMIZATION (Statistics); CALORIE; COMPARATIVE studies; COUNSELING; DIET therapy; HETEROCYCLIC compounds; RESEARCH methodology; MEDICAL cooperation; OBESITY; RESEARCH; STATISTICAL sampling; EVALUATION research; LIFESTYLES
- Publication
Obesity (19307381), 2018, Vol 26, Issue 2, p299
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22081