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- Title
Alleviation of Oxidative Stress in Dental Pulp Cells Following 4-Hexylresorcinol Administration in a Rat Model.
- Authors
Chang, Jun-Ho; Kim, Dae-Won; Kim, Seong-Gon; Kim, Tae-Woo; Narayan, Roger
- Abstract
Damaged dental pulp undergoes oxidative stress and 4-hexylresorcinol (4HR) is a well-known antioxidant. In this study, we aimed to evaluate the therapeutic effects of a 4HR ointment on damaged dental pulp. Pulp cells from rat mandibular incisor were cultured and treated with 4HR or resveratrol (1–100 μM). These treatments (10–100 μM) exerted a protective effect during subsequent hydrogen peroxide treatments. The total antioxidant capacity and glutathione peroxidase activity were significantly increased following 4HR or resveratrol treatment (p < 0.05), while the expression levels of TNF-α and IL1β were decreased following the exposure to 4HR pre-treatment in an in vitro model. Additionally, the application of 4HR ointment in an exposed dental pulp model significantly reduced the expression of TNF-α and IL1β (p < 0.05). Conclusively, 4HR exerted protective effects against oxidative stress in dental pulp tissues through downregulating TNF-α and IL1β.
- Subjects
DENTAL pulp; ANIMAL disease models; OXIDATIVE stress; OXIDANT status; GLUTATHIONE peroxidase
- Publication
Applied Sciences (2076-3417), 2021, Vol 11, Issue 8, p3637
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app11083637