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- Title
Role of caprin-1 in carcinogenesis.
- Authors
Yang, Zhuo-Shun; Qing, Hong; Gui, Hui; Luo, Jie; Dai, Long-Jun; Wang, Bin
- Abstract
RNA-binding proteins serve an essential role in post-transcriptional gene regulation. Cytoplasmic activation/proliferation-associated protein-1 (caprin-1) is an RNA-binding protein that participates in the regulation of cell cycle control-associated genes. Caprin-1 acts alone or in combination with other RNA-binding proteins, such as RasGAP SH3-domain-binding protein 1 and fragile X mental retardation protein. In the tumorigenesis process, caprin-1 primarily functions by activating cell proliferation and upregulating the expression of immune checkpoint proteins. Through the formation of stress granules, caprin-1 is also involved in the process by which tumor cells adapt to adverse conditions, which contributes to radiation and chemotherapy resistance. Given its role in various clinical malignancies, caprin-1 holds the potential to be used as a biomarker and a target for the development of novel therapeutics. The present review describes this newly identified putative oncogenic protein and its possible impact on tumorigenesis.
- Subjects
RNA-binding proteins; ONCOGENIC proteins; CELL cycle regulation; GENETIC regulation; INTELLECTUAL disabilities; CELL cycle proteins
- Publication
Oncology Letters, 2019, Vol 18, Issue 1, p15
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2019.10295