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- Title
Deregulation of microRNA‑193b affects the proliferation of liver cancer via myeloid cell leukemia‑1.
- Authors
Yin, WENjun; Nie, Yuehua; ChEN, Lingying; Wang, Quipping; Liu, Shuangquan; He, XiushENg; Wang, WENjun
- Abstract
Deregulation of microRNA (miR)‑193b has been revealed to be associated with the proliferation of liver cells. However, the interaction between miR‑193b and their targets inducing liver cancer remains largely unknown. The aim of the present study was to investigate the hypothesis that miR‑193b affects the proliferation of liver cancer cells. In the present study, the overall survival of patients with liver cancer and low fold change of miR‑193b was higher compared with that of patients with liver cancer patients and high fold change of miR‑193b. The expression level of myeloid cell leukemia‑1 (Mcl‑1) in patients with liver cancer was lower compared with in the control group. The results of the present study demonstrated that downregulation of miR‑193b suppressed the proliferation and induced apoptosis of liver cancer cells, and inhibited the Mcl‑1 protein expression level in liver cancer cells. Upregulation of miR‑193b increased cell proliferation and decreased apoptosis of liver cancer cells and promoted the expression level of Mcl‑1 protein. The results of the present study demonstrated that the expression of miR‑193b as a novel tumor suppressor serves an important role in the proliferation of liver cancer cells by mediating Mcl‑1 expression.
- Subjects
LIVER cancer; GENE expression; CANCER cell proliferation; DOWNREGULATION; MICRORNA; GENETICS
- Publication
Oncology Letters, 2018, Vol 15, Issue 3, p2781
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2017.7690